Grancalcin (GCA) Antibody

Grancalcin (GCA)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

GCA Antibody is a Rabbit Polyclonal antibody against GCA. This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.

PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.

GCA

Purified by affinity chromatography.