Protein Inhibitor of Activated STAT 1 (PIAS1) Antibody

Protein Inhibitor of Activated STAT 1 (PIAS1)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

PIAS1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in androgen receptor initiation and maintenance of spermatogenesis. The effects of transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.

PBS containing 0.09% sodium azide.

This product is for research use only.

PIAS1_HUMAN