Splicing Factor 3b Subunit 1 (SF3B1) Antibody

Splicing Factor 3b Subunit 1 (SF3B1)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].

PBS containing 0.09% sodium azide.

SF3B1

Purified through a protein A column, followed by peptide affinity purification.

Predicted to react with Xenopus SF3B1.