Myc Proto-Oncogene Protein (MYC) Antibody

Myc Proto-Oncogene Protein (MYC)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of the gene encoding MYC have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

PBS containing 0.09% sodium azide.

MYC

Purified through a protein A column, followed by peptide affinity purification.

Predicted to react with Mouse, Rat, Cow, Pig and Sheep MYC.