Anti-Noggin

Noggin, also known as NOG, is a protein which in humans is encoded by the NOG gene which maps to chromosome 17q22. Noggin binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-b superfamily, noggin may have a principal role in creating morphogenic gradients. It plays a key role in neural induction by inhibiting BMP4, along with other TGF-b signaling inhibitors such as chord in and follistatin.

Purified, in TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Store at 2-8C (Short Term). Aliquot and store at -20C for long term. Avoid repeated freeze and thaw cycles.

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