Mouse Monoclonal Antibody to RTN3

Mouse IgG2a

MW: 113kDa
Enterez GeneID: 10313
General Information: RTN3, reticulon 3. The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.
Immunogen: Purified recombinant fragment of RTN3 expressed in E. Coli.
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage: Reconstituted with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; IHC: 1 to 200 - 1 to 1000
References: 1. J Immunol. 2004 Jun 15; 172(12):7324-34. ; 2. J Mol Biol. 2007 Jul 20; 370(4):620-32.