Vergleich

DDR1 Antibody

ArtNr ABC-AM8458b-ev-80ul
Hersteller Abcepta
Menge 80 ul
Kategorie
Typ Antibody Monoclonal
Applikationen Western Blot, Immunohistochemistry
Specific against other
Host Mouse
Isotype IgG2b kappa
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, MCK-10, Protein-tyrosine kinase 3A,
Lieferbar
Primary Accession
Q08345
Bio Background
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Bio References
di Marco E., et al.J. Biol. Chem. 268:24290-24295(1993).
Johnson J.D., et al.Proc. Natl. Acad. Sci. U.S.A. 90:5677-5681(1993).
Laval S., et al.Cell Growth Differ. 5:1173-1183(1994).
Perez J.L., et al.Oncogene 9:211-219(1994).
Sakuma S., et al.FEBS Lett. 398:165-169(1996).
Gene ID
780
Gene Name
DDR1
Reactivity
H
Calculated MW
101128
Antigen Source
HUMAN
Target/Specificity
This DDR1 antibody is generated from a mouse immunized with a recombinant protein.

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Menge: 80 ul
Lieferbar: Out of stock
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