GPR56 Antibody

ArtNr	ABC-AM8687b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB
Specific against	other
Host	Mouse
Isotype	IgG1 kappa
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	GPR56, TM7LN4, TM7XN1, G-protein coupled receptor 56, Protein TM7XN1, GPR56 N-terminal fragment, GPR56 NT, GPR56(N), GPR56 extracellular subunit, GPR56 subunit alpha, GPR56 C-terminal fragment, GPR56 CT, GPR56(C), GPR56 seven-transmembrane subunit, GPR56 7TM, GPR56 subunit beta
Lieferbar
Primary Accession	Q9Y653
Application	WB
Bio Background	Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.
Bio References	Liu M., et al.Genomics 55:296-305(1999). Zendman A.J.W., et al.FEBS Lett. 446:292-298(1999). Kaighin V.A., et al.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases. Clark H.F., et al.Genome Res. 13:2265-2270(2003). Ota T., et al.Nat. Genet. 36:40-45(2004).
Clonality	monoclonal
Clone/Animal Names	1443CT642.85.27
Gene ID	9289
Gene Name	ADGRG1 (HGNC:4512)
Subtitle	Purified Mouse Monoclonal Antibody (Mab)
Reactivity	H
Legend image 1	All lanes : Anti-GPR56 Antibody at 1:1000 dilution Lane 1: Hela whole cell lysates Lane 2: U87-MG whole cell lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 78 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Type image 1	WB
Dilution image 1	1:1000
Isotype	IgG1, k
Calculated MW	77738
Antigen Region	Recombinant Protein
Antigen Source	HUMAN
Target/Specificity	This antibody is generated from a mouse immunized with a recombinant protein.

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Menge: 400 ul

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