GPR56 Antibody

Q9Y653

Involved in cell adhesion and probably in cell-cell interactions. Regulates the migration of neural precursor cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. Isoforms show differences in receptor signaling, specifically in serum response element (SRE) transcriptional activation upon overexpression. Overexpression inhibits melanoma tumor growth and metastasis and, during melanoma progression, regulates VEGFA production and angiogenesis through PRKCA; unprocessed GPR56 is inhibiting and GPR56 NT is activating angiogenesis.

monoclonal

9289

Purified Mouse Monoclonal Antibody (Mab)

All lanes : Anti-GPR56 Antibody at 1:1000 dilution
Lane 1: Hela whole cell lysates
Lane 2: U87-MG whole cell lysates

Lysates/proteins at 20 μg per lane.

Secondary
Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution

Predicted band size : 78 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

1:1000

77738

HUMAN