TGIF Antibody (Center L223)

Synthetic Peptide

TGIF1 is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.

Polyclonal

7050

Purified Rabbit Polyclonal Antibody (Pab)

Western blot analysis of anti-TGIF1 Antibody (Center L223) (RB14109) in Y79 cell line lysates (35ug/lane). TGIF1(arrow) was detected using the purified Pab.

1:1000

C, M

43013

HUMAN

NP_001265611.1; NP_001265613.1; NP_001265615.1; NP_003235.1; NP_733796.2; NP_775299.1; NP_775300.1; NP_775301.1; NP_775302.1; NP_775303.1; NP_777480.1