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ABL1 Antibody (N-term H246)

ABL1 Antibody (N-term H246)

ArtNr	ABC-AP7694C
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Applikationen	WB
Specific against	other
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	ABL1, Tyrosine-protein kinase ABL1, Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, Proto-oncogene c-Abl, p150, ABL, JTK7
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Primary Accession	P00519
Antigen Type	Synthetic Peptide
Application	WB
Bio Background	The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9; 22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.
Bio References	Donaldson, L.W., et al., Proc. Natl. Acad. Sci. U.S.A. 99(22):14053-14058 (2002). Pisabarro, M.T., et al., J. Mol. Biol. 281(3):513-521 (1998). Nam, H.J., et al., Structure 4(9):1105-1114 (1996). Chissoe, S.L., et al., Genomics 27(1):67-82 (1995). Gosser, Y.Q., et al., Structure 3(10):1075-1086 (1995).
Clonality	Polyclonal
Clone/Animal Names	RB7355
Gene ID	25
Gene Name	ABL1
Subtitle	Affinity Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of ABL1 Antibody (N-term H246) (Cat.#AP7694c) in Y79 cell line lysates (35ug/lane). ABL1(arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Other Accession	P00520; F8W5Q8
Predicted	Zf, M
Isotype	Rabbit IgG
Calculated MW	122873
Antigen Region	231-260
Antigen Source	HUMAN
Target/Specificity	This ABL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the N-terminal region of human ABL1.
NCBI Accession	NP_005148.2; NP_009297.2

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Menge: 400 ul

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