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BRK (PTK6) Antibody (N-term)

BRK (PTK6) Antibody (N-term)

ArtNr	ABC-AP7715a
Hersteller	Abcepta
Menge	400 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Format	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Applikationen	WB, IHC-P
Specific against	other
Host	Rabbit
Isotype	Ig
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	PTK6, Protein-tyrosine kinase 6, BRK, Breast tumor kinase, Tyrosine-protein kinase BRK
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Primary Accession	Q13882
Antigen Type	Synthetic Peptide
Application	IHC-P, WB
Bio Background	PTK6 is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation.
Bio References	Derry, J.J., et al., Oncogene 22(27):4212-4220 (2003). Coyle, J.H., et al., Mol. Cell. Biol. 23(1):92-103 (2003). Koo, B.K., et al., J. Biochem. Mol. Biol. 35(3):343-347 (2002). Kang, K.N., et al., Biochim. Biophys. Acta 1574(3):365-369 (2002). Hong, E., et al., J. Biomol. NMR 19(3):291-292 (2001).
Clonality	Polyclonal
Clone/Animal Names	RB3073/3074
Gene ID	5753
Gene Name	PTK6
Subtitle	Purified Rabbit Polyclonal Antibody (Pab)
Reactivity	H
Legend image 1	Western blot analysis of anti-hPTK6-E26 Pab (Cat. #AP7715a) in A375 cell line lysate (35ug/lane). hPTK6-E26(arrow) was detected using the purified Pab.
Type image 1	WB
Dilution image 1	1:1000
Legend image 2	Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Type image 2	IHC-P
Dilution image 2	1:50~100
Isotype	Rabbit Ig
Calculated MW	51834
Antigen Region	11-41
Antigen Source	HUMAN
Target/Specificity	This BRK (PTK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 amino acids from the N-terminal region of human BRK (PTK6).
NCBI Accession	NP_001243287.1; NP_005966.1

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 400 ul

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