ZNF346 (CT) Antibody

ArtNr	ABC-ASC11287
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Primary Accession	Q9UL40
Application	WB, IHC-P, IF, E
Bio Background	ZNF346 (CT) Antibody: ZNF346, also known as JAZ (just another zinc-finger protein), is a nucleolar, zinc finger protein which preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids with high affinity via C2H2 zinc fingers. ZNF346 contains four CH-type zinc finger motifs that are connected by long (28-38) amino acid linker sequences. ZNF346 is expressed in all tissues tested and localizes to the nucleus, primarily the nucleolus. ZNF346 is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism. ZNF346 interacts with ILF3 in an RNA-independent manner and may be involved in cell growth and survival.
Bio References	Rosenfeld R and Margalit H. Zinc fingers: conserved properties that can distinguish between spurious and actual DNA-binding motifs. J. Biomol. Struct. Dyn. 1993; 11:557-70. Simpson JC, Wellenreuther R, Poustka A, et al. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. EMBO Rep. 2000; 1:287-92. Yang M, May WS, and Ito T. JAZ requires the double-stranded RNA-binding zinc-finger motifs for nuclear localization. J. Biol. Chem. 1999; 274: 27399-406. Chen T, Brownawell AM, and Macara IG. Nucleocytoplasmic shuttling of JAZ, a new cargo protein for Exportin 5. Mol. Cell. Biol. 2004; 24:6608-19.
Clonality	Polyclonal
Gene ID	23567
Gene Name	ZNF346
Reactivity	H, M
Legend image 1	Western blot analysis of ZNF346 in human kidney tissue lysate with ZNF346 antibody at (A) 1 and (B) 2 µg/mL.
Type image 1	WB
Legend image 2	Immunohistochemistry of ZNF346 (CT) in human kidney tissue with ZNF346 (CT) antibody at 5 µg/mL.
Type image 2	IHC
Legend image 3	Immunofluorescence of ZNF346 in human kidney tissue with ZNF346 antibody at 20 µg/mL.
Type image 3	IF
Other Accession	NP_036411; 6912440
Isotype	IgG
Calculated MW	32933
Antigen Source	Homo sapiens
Target/Specificity	ZNF346; ZNF346 antibody is predicted to not cross-react with other ZNF family members. Three isoforms of ZNF346 are known to exist; this antibody will recognize the two longest isoforms
Purification	ZNF346 (CT) Antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	ZNF346 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Antibody Form	Liquid
Application Notes	ZNF346 antibody can be used for detection of ZNF346 by Western blot at 1 - 2 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Positive Control	Human Kidney Tissue Lysate;
Buffer	ZNF346 (CT) Antibody is supplied in PBS containing 0.02% sodium azide.

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ABC-ASC11287-datasheet.pdf

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Menge: 100 ug

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Lieferung vsl. bis 04.09.2025