USP25 Antibody

ArtNr	ABC-ASC11789
Hersteller	Abcepta
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB, IF, ELISA, IHC-P
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Primary Accession	Q9UHP3
Application	WB, IHC-P, IF, E
Bio Background	USP25 (ubiquitin specific peptidase 25), also known as USP21, belongs to the peptidase C19 family and is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response (1). It contains one UBA-like domain and two UIM (ubiquitin-interacting motif) repeats. Due to alternative splicing events, USP25 is expressed as two short, ubiquitously expressed isoforms and one long, muscle-specific isoform (2). The long isoform of USP25 (USP25m) is upregulated in myogenesis and is implicated in regulation of muscular differentiation and function. USP25 is a deubiquitinating enzyme (DUB) that negatively regulates IL-17-triggered signaling (3, 4).
Bio References	Valero R, Marfany G, Gonzalez-Angulo O, et al. USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics 1999; 62:395-405. Valero R, Bayes M, Francisca Sanchez-Font M, et al. Characterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25. Genome Biol. 2001; 2: RESEARCH0043. Zhong B, Liu X, Wang X, et al. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. Nat. Immunol. 2012; 13:1110-7. Zhong B, Liu X, Wang X, et al. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3. Sci. Signal. 2013; 6:ra35.
Clonality	Polyclonal
Gene ID	29761
Gene Name	USP25
Reactivity	H, M
Legend image 1	Western blot analysis of USP25 in mouse brain tissue lysate with USP25 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide.
Type image 1	WB
Legend image 2	Immunohistochemistry of USP25 in human brain tissue with USP25 antibody at 5 µg/mL.
Type image 2	IHC
Legend image 3	Immunofluorescence of USP25 in human brain tissue with USP25 antibody at 20 µg/mL.
Type image 3	IF
Other Accession	NP_037528; 50312666
Isotype	IgG
Calculated MW	122218
Antigen Source	homo sapiens
Target/Specificity	USP25; USP25 antibody is human and mouse reactive. Multiple isoforms of USP25 are known to exist.
Purification	USP25 antibody is affinity chromatography purified via peptide column.
Reconstitution & Storage	USP25 antibody can be stored at 4℃ for three months and -20℃, stable for up to one year.
Antibody Form	Liquid
Application Notes	USP25 antibody can be used for detection of USP25 by Western blot at 1 - 2 µg/ml. Antibody can also be used for Immunohistochemistry at 5 µg/mL. For Immunoflorescence start at 20 µg/mL.
Positive Control	Mouse Brain Tissue Lysate;
Buffer	USP25 Antibody is supplied in PBS containing 0.02% sodium azide.

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Menge: 100 ug

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