FCGR3A Antibody (monoclonal) (M03)

P08637

WB, E

[Fcgamma ReceptorIIIa Polymorphism in Healthy Children and Those with Hematological Malignancies.] Qu YH, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2010 Jul. PMID 20723308.Functional polymorphisms of PTPN22 and FcgR genes in Tunisian patients with rheumatoid arthritis. Sfar I, et al. Arch Inst Pasteur Tunis, 2009. PMID 20707220.Effect of FCGR2A and FCGR3A variants on CLL outcome. Dornan D, et al. Blood, 2010 Aug 12. PMID 20705761.Fragment c gamma receptor gene polymorphisms and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Iwasaki M, et al. Breast Cancer Res Treat, 2010 Aug 10. PMID 20697800.The loss of the CD16 B73.1/Leu11c epitope occurring in some primary immunodeficiency diseases is not associated with the FcgammaRIIIa-48L/R/H polymorphism. Lenart M, et al. Int J Mol Med, 2010 Sep. PMID 20664961.

2214

Mouse monoclonal antibody raised against a full-length recombinant FCGR3A.

Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (51.92 KDa) .

1:500~1000

WB

Detection limit for recombinant GST tagged FCGR3A is approximately 1ng/ml as a capture antibody.

BC017865

Human: ~~ Positive

NP_000560.5; NP_001121064.1; NP_001121065.1; NP_001121067.1; NP_001121068.1

AAH17865.1

This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq