Tyrosinase-Related Protein-1 (TYRP-1) (Melanoma Marker)(TYRP1/3280), CF405S conjugate, 0.1mg/mL

Primary

Antibodies

CF405S

Store at 2 to 8°C|Protect fluorescent conjugates from light

Reacts with a 75 kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Protect from light

Stable at room temperature or 37°C (98°F) for 7 days.

Primary and secondary antibodies for multiple methodology
immunostaining detection application

0.1 mg/mL

Guaranteed for at least 24 months from date of receipt when stored as recommended

Monoclonal

TYRP1

SK-MEL-23, SK-MEL-19, SK-MEL-30, SK-MEL-37 cells. Human skin or melanoma tissues (IHC).

Melanocytes

Monospecific