GITR / Tnfrsf18 (Mouse)(DTA-1), CF568 conjugate, 0.1mg/mL

Primary

Antibodies

CF568

Room temperature

66-70 kDa (Homodimer)

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Mus musculus (mouse), BSA from bovine serum (Bos taurus) or recombinant BSA produced in Chinese hamster ovary cells.

2 years

41116161

0.05% sodium azide (CAS 26628-22-8)

PBS, 0.1% BSA, 0.05% azide

Mouse CD25 CD4 T cells

For research use only (RUO)

3180

Plasma membrane

Flow cytometry: 0.5-1 ug/million cells in 0.1 mL|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 0.5-1 ug/mL|Optimal dilution for a specific application should be determined by user

GITR|Tnfrsf18