POLD1 Antibody

POLD1

Polymerase (DNA directed) delta 1 catalytic subunit antibody; CDC2 antibody; CDC2 homolog antibody; CRCS10 antibody; DNA directed DNA polymerase delta 1 antibody; DNA directed polymerase delta 1 antibody; DNA pol delta 1 antibody; DNA polymerase delta catalytic subunit antibody; DNA polymerase subunit delta p125 antibody; DPOD1_HUMAN antibody; MDPL antibody; POLD antibody; POLD 1 antibody; POLD1 antibody; Polymerase (DNA directed) delta 1 catalytic subunit 125kDa antibody; Polymerase (DNA) delta 1 catalytic subunit antibody; Polymerase DNA directed delta 1 catalytic subunit 125kD antibody; polymerase, DNA, delta antibody

Recombinant Human DNA polymerase delta catalytic subunit protein (1-123AA)

As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200, PubMed:24022480). Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4), displays differences in catalytic activity. Most notably, expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, in the presence of POLD3 and POLD4, may catalyze the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196).

>95%, Protein G purified

Epigenetics and Nuclear Signaling

Recombinant Human DNA polymerase delta catalytic subunit protein (1-123AA)