IL23A Recombinant Monoclonal Antibody

ELISA, WB; Recommended dilution: WB:1:500-1:5000

IL23A

A synthesized peptide derived from human IL23

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Affinity-chromatography

Cancer; Immunology

A synthesized peptide derived from human IL23