PDK1 antibody

ArtNr	FNab06276-100ug
Hersteller	FineTest
Menge	100 ug
Quantity options	100 ug 100 ug 100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Purity	≥95% as determined by SDS-PAGE
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1,mitochondrial,Pyruvate dehydrogenase kinase isoform 1 (PDH kinase 1),PDK1,PDHK1
Lieferbar
Manufacturer - Targets	PDK1
Storage Conditions	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Clonality	polyclonal
Immunogen	pyruvate dehydrogenase kinase, isozyme 1
Observed MW	46-55 kDa
Purification	Immunogen affinity purified
Recommended dilution	WB: 1:500-1:2000; IHC: 1:20-1:200
Manufacturer - Research Area	Signal Transduction, Metabolism

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