Anti-Mouse IL-1b (B122) In Vivo Antibody - Low Endotoxin

Neutralization, Immunoprecipitation, Western Blot, ELISA

Armenian Hamster IgG

Blue ice

Aggregation level ≤ 5%

Monocytes, tissue macrophages, Langerhan cells, dendritic cells, T lymphocytes, B lymphocytes, natural killer (NK) cells and many other B cells, T cells, related monocytes

Interleukin 1 beta (IL1 beta) is a proinflammatory cytokine belonging to IL1 family that is synthesized as a precursor. The IL1 beta precursor form is not biologically active. It is expressed mainly by stimulated macrophages and monocytes. IL1 beta is known to be a mediator in inflammatory response and to be involved in a variety of cellular activities, proliferation, differentiation and apoptosis. It has been recently found that IL1 beta is a major cause of severe inflammation in the mouse model of Crohns disease which makes IL1 beta an important target for this disease. The B122 antibody has been reported to neutralize the bioactivity of natural or recombinant IL-1β.

≤ 1.0 EU/mg as determined by the LAL method

This monoclonal antibody was purified using Protein A

E. coli -expressed, recombinant mouse IL-1β

ICH3001-100ml; ICH3002-100ml; ICH3003-100ml