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Anti-Human TGF-β Activated Protein Kinase 1 (TAK1)

Anti-Human TGF-β Activated Protein Kinase 1 (TAK1)

ArtNr	LEIN-T276-0.1mg
Hersteller	Leinco Technologies
Menge	0.1 mg
Quantity options	0.1 mg 20 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
Citations	1. Yamaguchi, K. et al. (1995) Science 270:2008 2. Irie, T. et al. (2000) FEBS Lett. 467:160 3. Akira, S. et al. (2004) Nat. Rev. Immunol. 4:499 4. Jiang, Z. et al. (2002) Mol. Cell Biol. 22:7158
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Category	Primary Monoclonal Antibodies>Apoptosis & Cell Biology
Manufacturer - Targets	TAK1
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Product Description	TAK1 (TGF-β; activated protein kinase 1) is a widely expressed enzyme originally identified as a mitogen-activated protein kinase kinase kinase (MAP3K7).1 It has since been shown to mediate various intracellular signaling pathways, such as those induced by TGF-Β and members of the Toll-IL-1R (TIR) superfamily, 2 thus acting as an intermediate in both proliferative and innate and adaptive immune responses.3 TAK1 is normally present in cells in a complex with TAK1-binding protein 1 (TAB1) and either TAB2 or TAB3.4 Association with TAB1 triggers TAK1 kinase activity by inducing TAK1 autophosphorylation, while TAB2 and possibly TAB3 may contribute to SAPK2a/p38a-mediated feedback inhibition of TAK1 activity.
Background	TAK1 (TGF-β; activated protein kinase 1) is a widely expressed enzyme originally identified as a mitogen-activated protein kinase kinase kinase (MAP3K7).¹ It has since been shown to mediate various intracellular signaling pathways, such as those induced by TGF-Β and members of the Toll-IL-1R (TIR) superfamily, ² thus acting as an intermediate in both proliferative and innate and adaptive immune responses.³ TAK1 is normally present in cells in a complex with TAK1-binding protein 1 (TAB1) and either TAB2 or TAB3.⁴ Association with TAB1 triggers TAK1 kinase activity by inducing TAK1 autophosphorylation, while TAB2 and possibly TAB3 may contribute to SAPK2a/p38a-mediated feedback inhibition of TAK1 activity.
PubMed	TAK1
Manufacturer - Specificity	Rabbit Anti-Human TGF-β Activated Protein Kinase 1 (TAK1) recognizes Human, Mouse and Rat TAK1. This polyclonal antibody was purified using affinity chromatography.
RRID	AB_2831873
Concentration	0.5 mg/ml
Formulation	This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.
Immunogen	PN:T303
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

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LEIN-T276-0.1mg-safety-datasheet.pdf