SDHAF2 Antibody

ArtNr	PRS-6507-0.02mg
Hersteller	ProSci
Menge	0.02 mg
Quantity options	0.02 mg 0.1 mg
Kategorie	Oncology Antibodies Western Blot ELISA Primary Antibodies By Organ Thyroid Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Chicken
Isotype	IgY
Konjugat/Tag	Unconjugated
Citations	Hao HX, Khalimonchuk O, Schraders M, et al. SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science 2009; 325:1139-42. Burnichon N, Brière JJ, Libé R, et al. SDHA is a tumor suppressor gene causing paraganglioma. Hum. Mol. Genet. 2010; 19:3011-20. Kunst HP, Rutten MH, de Monnink JP, et al. SDHAF2 (PGL2-SDH5) and hereditary head and neck paraganglioma. Clin. Cancer Res. 2011; 17:247-54 Starker LF, Delgado-Verdugo A, Udelsman R, et al. Expression and somatic mutations of SDHAF2 (SDH5), a novel endocrine tumor suppressor gene in parathyroid tumors of primary hyperparathyroidism. Endocrine 2010; 38:397-401.
NCBI	SDHAF2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	SDHAF2 Antibody: PGL2, SDH5, C11orf79, PGL2, Succinate dehydrogenase assembly factor 2, mitochondrial, Succinate dehydrogenase subunit 5, SDH assembly factor 2
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Manufacturer - Applications	SDHAF2 antibody can be used for detection of SDHAF2 by Western blot at 1 μg/mL. Antibody validated: Western Blot in rat samples. All other applications and species not yet tested.
Shipping Temperature	blue ice or room temperature
Storage Conditions	SDHAF2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Manufacturer - Research Area	Cancer, Cell Cycle
Background	SDHAF2 Antibody: SDHAF2 (Succinate dehydrogenase complex assembly factor 2) encodes a mitochondrial protein needed for FAD cofactor attach to the SDH enzyme which plays a critical role in mitochondria. SDHAF2 is a tumor suppressor, but recent evidence suggests that somatic mutations of the SDHAF2 are unlikely to contribute to parathyroid tumor development in sporadic primary hyperparathyroidism.
Protein Gi #	8923450
Purification	SDHAF2 Antibody is affinity chromatography purified via peptide column.
Positive Control 1	PRS-1464-0.1mg
Concentration	1 mg/ml
Buffer	SDHAF2 Antibody is supplied in PBS containing 0.02% sodium azide.
Homology	Predicted species reactivity based on immunogen sequence: Bovine: (93%)
Immunogen	SDHAF2 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human SDHAF2. The immunogen is located within the first 50 amino acids of SDHAF2.
Clonality	Polyclonal
NCBI Official Name	succinate dehydrogenase complex
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

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Menge: 0.02 mg

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