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Anti-HP1 alpha Antibody ChIP Grade

Anti-HP1 alpha Antibody ChIP Grade

ArtNr	BOS-CI1057
Hersteller	Boster
Menge	50 ug/25 ul
Kategorie	Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody
Applikationen	WB, IF, IHC
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Chromobox protein homolog 5,Antigen p25,Heterochromatin protein 1 homolog alpha,HP1 alpha,CBX5,HP1A,
Lieferbar
Storage Conditions	At -20°C for one year, at 4°C for one month. Avoid repeated freezing and thawing.
Observed Molecular Weight	22225 MW
Clonality	Polyclonal
Manufacturer - Gene Name	CBX5
Background	HP1 alpha is a component of heterochromatin. It recognizes and binds to histone H3 tails methylated at a€˜Lys-9a€, leading to epigenetic repression of transcription. HP1 alpha may also interact with lamin B receptor (LBR), thereby contributing to the association of the heterochromatin with the inner nuclear membrane. Further, HP1 alpha is involved in the formation of a functional kinetochore through interaction with MIS12 complex proteins.
Immunogen	This antibody is raised in rabbit against human HP1?? (Heterochromatin protein 1 homolog alpha), using the full length recombinant GST tagged protein.
Contents	Protein G purified polyclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300.
Purification	Protein G purified
Manufacturer - Research Category	\|epigenetics and nuclear signaling\|chromatin binding proteins\|methyl lysine\| tags & cell markers\|subcellular markers\|nucleus\|chromatin\| epigenetics and nuclear signaling\|chip'ing antibodies
Protein Function	Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.

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BOS-CI1057-datasheet.pdf

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