Anti-Phospho Girdin (Ser1417) CCDC88A Antibody

Rabbit IgG

216042 MW

Immunohistochemistry, 1:100 - 1:300
ELISA, 1:5000
Not yet tested in other applications.

Girdin

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB, but does not possess kinase activity itself. Phosphorylation of AKT1/PKB thereby induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton and for cell migration. Required for formation of actin stress fibers and lamellipodia. May be involved in membrane sorting in the early endosome.

Boster Bio Anti-Phospho Girdin (Ser1417) CCDC88A Antibody (Catalog# P03282). Tested in IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse.

Expressed ubiquitously.