GANP Colorimetric Cell-Based ELISA Kit

Cell-Based ELISA Kits

218405 MW

Germinal-center associated nuclear protein

Isoform GANP: Essential for the generation of high- affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation- dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly (A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.

The GANP Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor GANP protein expression profile in cells. The kit can be used for measuring the relative amounts of GANP in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on GANP.