H-Ile-Pro-Pro-OH (hydrochloride)

1208862-61-6

361.86

H2O : 55 mg/mL (151.99 mM; Need ultrasonic); DMSO : 36.67 mg/mL (101.34 mM; Need ultrasonic)

Metabolic Enzyme/Protease

H-Ile-Pro-Pro-OH hydrochloride, a milk-derived peptide^[1], inhibits angiotensin-converting enzyme (ACE)^[1] with an IC₅₀ of 5 uM^[2]. Antihypertensive tripeptides^[1]. IC50 & Target: IC50: 5 uM (ACE)^[2] In Vitro: Ile-Pro-Pro (IPP; 1 nM, 0.1 uM, and 10 uM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)^[1]. In Vivo: Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats^[1]
Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) ^[1].
Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice^[1].