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BCL-2 (Phospho-Ser70) Antibody Blocking Peptide

BCL-2 (Phospho-Ser70) Antibody Blocking Peptide

ArtNr	06-785-213062
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology By Cell Type Blastoma Carcinoma Hematology Leukemia Lymphoma Myeloma Peptides & Proteins Cell Biology Cell Status Apoptosis Autophagy Peptides By Organ Colorectal Cancer Testicular & Prostate Cancer
Typ	Peptides
Specific against	other
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	GWB-B2BCC1
Similar products	06-785-213062
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Genway ID:	GWB-B2BCC1
Function:	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Subunit:	Forms homodimers and heterodimers with BAX BAD BAK and Bcl-X(L). Heterodimerization with BAX requires intact BH1 and BH2 motifs and is necessary for anti-apoptotic activity (By similarity). Also interacts with APAF1 RAF-1 TP53BP2 BBC3 BCL2L1 MRPL41 and BNIPL. Binding to FKBP8 seems to target BCL2 to the mitochondria and probably interferes with the binding of BCL2 to its targets.
Subcellular Location:	Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue Specificity:	Expressed in a variety of tissues.
Domain:	The BH4 motif is required for anti-apoptotic activity and for interaction with RAF-1.
Ptm:	Phosphorylation/dephosphorylation on Ser-70 regulates anti-apoptotic activity. Growth factor-stimulated phosphorylation on Ser-70 by PKC is required for the anti-apoptosis activity and occurs during the G2/M phase of the cell cycle. In the absence of growth factors BCL2 appears to be phosphorylated by other protein kinases such as ERKs and stress-activated kinases. Dephosphorylated by protein phosphatase 2A (PP2A) (By similarity).
Ptm:	Proteolytically cleaved by caspases during apoptosis. The cleaved protein lacking the BH4 motif has pro-apoptotic activity causes the release of cytochrome c into the cytosol promoting further caspase activity.
Disease:	A chromosomal aberration involving BCL2 may be a cause of follicular lymphoma (FL) [MIM:151430]; also known as type II chronic lymphatic leukemia. Translocation t(14; 18)(q32; q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
Similarity:	Belongs to the Bcl-2 family.

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Menge: 0.1 mg

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Lieferung vsl. bis 28.08.2025

Express-Lieferung: 6 Tage sparen

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