FELINE IMMUNODEFICIENCY VIRUS p24 gag

GWB-AA7524

IgG1

This product recognises a p24 epitope of feline immunodeficiency virus (FIV) p24 gag distinct from the p24 epitope recognised by 20-783-71840. The lentivirus FIV responsible for a progressive and debilitating immune deficiency syndrome in domestic cats similar to that caused by the human Immunodeficiency Virus (HIV) is a complex retrovirus with a tightly-packed genome containing the structural genes gag env and pro-pol and the accessory genes vif rev and ORF-A/2. This product does not recognise Feline Leukaemia Virus (FeLV) Feline Herpes Virus (FHV) type 1 Feline Coronavirus or Feline Calicivirus. This product can be used as a capture reagent in ELISA assays in combination with 20-783-74825 as a detection reagent.

Phosphate buffered saline pH7. 2

Western Blot: This product detects a dominant band of approximately 24kDa under reducing conditions.

Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).

Matrix protein p15: Virion (Potential).

Nucleocapsid protein p13: Virion (Potential).

Contains 2 CCHC-type zinc fingers. 1. Lerner. D. L. et al. (1995) Increased mutation frequency of Feline Immunodeficiency Virus lacking functional deoxyuridine-triphosphatase. 2. Chatterji. U. et al. (2000) Feline Immunodeficiency Virus Vif localises to the nucleus. J. Virol. 74: 2533-2540. 3. Norway. R. M. et al. (2001) Thymic lesions in cats infected with a pathogenic molecular clone or an ORF-A/2 -deficient molecular clone of Feline Immunodeficiency Virus. 4. Simon. J. H. M. et al. (1997) The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cells.