CASP8 Antibody

ArtNr	CSB-PA18109A0Rb-50ug
Hersteller	Cusabio
Menge	50 ug
Quantity options	100 ug 20 ug 50 ug
Kategorie	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Immunofluorescence Primary Antibodies By Organ Colorectal Cancer Testicular & Prostate Cancer Gastric Cancer Uterine, Ovarian & Cervical Cancer
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ALPS2B antibody; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein antibody; Apoptosis related cysteine peptidase antibody; Apoptotic cysteine protease antibody; Apoptotic protease Mch-5 antibody; Apoptotic protease Mch5 antibody; CAP 4 antibody; CAP4 antibody; CASP-8 antibody; CASP8 antibody; CASP8_HUMAN antibody; Caspase 8 antibody; Caspase 8 apoptosis related cysteine peptidase antibody; Caspase IIX antibody; Caspase-8 subunit p10 antibody; caspase8 antibody; CED 3 antibody; FADD Homologous ICE/CED3 Like Protease antibody; FADD Like ICE antibody; FADD-homologous ICE/CED-3-like protease antibody; FADD-like ICE antibody; FLICE antibody; FLJ17672 antibody; ICE-like apoptotic protease 5 antibody; MACH alpha 1/2/3 protein antibody; MACH antibody; MACH beta 1/2/3/4 protein antibody; MACH5 antibody; MCH 5 antibody; MCH5 antibody; MGC78473 antibody; MORT1 associated ced 3 homolog antibody; MORT1 associated CED3 homolog antibody; MORT1-associated CED-3 homolog antibody; OTTHUMP00000163717 antibody; OTTHUMP00000163720 antibody; OTTHUMP00000163724 antibody; OTTHUMP00000163725 antibody; OTTHUMP00000165062 antibody; OTTHUMP00000165063 antibody; OTTHUMP00000165064 antibody; OTTHUMP00000206552 antibody; OTTHUMP00000206582 antibody
Similar products	CASP8, MCH5, Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Casp, Caspase-8 subunit p10]
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Manufacturer - Type	Polyclonal Antibody
Manufacturer - Targets	CASP8
Storage Conditions	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Manufacturer - Alias	ALPS2B antibody; Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein antibody; Apoptosis related cysteine peptidase antibody; Apoptotic cysteine protease antibody; Apoptotic protease Mch-5 antibody; Apoptotic protease Mch5 antibody; CAP 4 antibody; CAP4 antibody; CASP-8 antibody; CASP8 antibody; CASP8_HUMAN antibody; Caspase 8 antibody; Caspase 8 apoptosis related cysteine peptidase antibody; Caspase IIX antibody; Caspase-8 subunit p10 antibody; caspase8 antibody; CED 3 antibody; FADD Homologous ICE/CED3 Like Protease antibody; FADD Like ICE antibody; FADD-homologous ICE/CED-3-like protease antibody; FADD-like ICE antibody; FLICE antibody; FLJ17672 antibody; ICE-like apoptotic protease 5 antibody; MACH alpha 1/2/3 protein antibody; MACH antibody; MACH beta 1/2/3/4 protein antibody; MACH5 antibody; MCH 5 antibody; MCH5 antibody; MGC78473 antibody; MORT1 associated ced 3 homolog antibody; MORT1 associated CED3 homolog antibody; MORT1-associated CED-3 homolog antibody; OTTHUMP00000163717 antibody; OTTHUMP00000163720 antibody; OTTHUMP00000163724 antibody; OTTHUMP00000163725 antibody; OTTHUMP00000165062 antibody; OTTHUMP00000165063 antibody; OTTHUMP00000165064 antibody; OTTHUMP00000206552 antibody; OTTHUMP00000206582 antibody
Immunogen Species	Human
Immunogen	Recombinant Human Caspase-8 protein (217-374AA)
Dilution	ELISA:1:2000-1:10000 WB:1:500-1:2000 IHC:1:10-1:100 IF:1:50-1:200
Background	Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-\|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
Buffer	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method	>95%, Protein G purified
General Research Areas	Cell Biology
Initial Research Areas	Cell Biology
Antigen Species	Human
Antigen	Recombinant Human Caspase-8 protein (217-374AA)
Clonality	Polyclonal

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Menge: 50 ug

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Lieferung vsl. bis 11.09.2025