WNK4 Antibody

WNK4

PHA 2B antibody; PHA2B antibody; PRKWNK 4 antibody; PRKWNK4 antibody; Protein kinase lysine deficient 4 antibody; Protein kinase lysine-deficient 4 antibody; Protein kinase with no lysine 4 antibody; Serine/threonine protein kinase WNK4 antibody; Serine/threonine-protein kinase WNK4 antibody; WNK lysine deficient protein kinase 4 antibody; Wnk4 antibody; WNK4_HUMAN antibody

Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA)

Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-independent mechanism by which it induces clearance of the protein from the cell surface by clathrin-dependent endocytosis. WNK4 appears to act as a molecular switch that can vary the balance between NaCl reabsorption and K(+) secretion to maintain integrated homeostasis. Phosphorylates NEDD4L. Acts as a scaffold to inhibit SLC4A4 as well as CFTR activities and surface expression, recruits STK39 which mediates the inhibition (By similarity).

>95%, Protein G purified

Signal Transduction

Recombinant Human Serine/threonine-protein kinase WNK4 protein (828-1106AA)