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Recombinant Human Tumor necrosis factor receptor superfamily member 12A protein(TNFRSF12A),partial (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 12A protein(TNFRSF12A),partial (Active)

ArtNr	CSB-AP001931HU-1
Hersteller	Cusabio
Menge	1 mg
Quantity options	1 mg 100 ug 25 ug 250 ug 5 ug 500 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human (Homo sapiens)
Purity	>95% as determined by SDS-PAGE and HPLC.
Sequence	EQAPGTAPCS RGSSWSADLD KCMDCASCRA RP HSDFCLGC AAAPPAPFRL LWP
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, TweakR, CD antigen CD266,
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Manufacturer - Category	Cytokine / Tumor Necrosis Factor
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	5.6 kDa
General Research Areas	Cancer
Relevance	Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269\|PubMed:11728344}.
Function	Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Subcellular Location	Membrane, Single-pass type I membrane protein
Tissue Specificity	Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
Gene Names	TNFRSF12A, FN14
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Uniprot Entry Name	TNR12_HUMAN
Expression Region	28-80aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by inhibiting TWEAK- dependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 30 ng/ml, corresponding to a specific activity of ? 3.3 x 104 IU/mg, in the presence of 15 ng/ml of rHuTWEAK.
PubMed ID	10751351; 15489334; 11728344; 19241374

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CSB-AP001931HU-1-datasheet.pdf

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Menge: 1 mg

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Lieferung vsl. bis 28.08.2025

Express-Lieferung: 3 Tage sparen

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