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Recombinant Human Tumor necrosis factor receptor superfamily member 17 protein(TNFRSF17),partial (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 17 protein(TNFRSF17),partial (Active)

ArtNr	CSB-AP002271HU-1
Hersteller	Cusabio
Menge	1 mg
Quantity options	1 mg 100 ug 20 ug 250 ug 5 ug 500 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human (Homo sapiens)
Purity	>98% as determined by SDS-PAGE and HPLC.
Sequence	AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LT CQRYCNAS VTNSVKGTNA
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	B-cell maturation protein,
Lieferbar
Manufacturer - Category	Cytokine / Tumor Necrosis Factor
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	5.4 kDa
General Research Areas	Cancer
Relevance	Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269\|PubMed:10801128, ECO:0000269\|PubMed:10903733, ECO:0000269\|PubMed:10973284}.
Function	Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Subcellular Location	Cell membrane, Single-pass type III membrane protein, Endomembrane system, Single-pass type III membrane protein
Tissue Specificity	Expressed in mature B-cells, but not in T-cells or monocytes.
Involvement in disease	A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4; 16)(q26; p13) with IL2.
Gene Names	TNFRSF17, BCM, BCMA
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered 30 % acetonitrile, 0.1 % TFA , lyophilized
Uniprot Entry Name	TNR17_HUMAN
Expression Region	5-54aa
Protein Description	Partial
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is no less than 40 ng/ml, corresponding to a specific activity of ? 2.5 x 104 IU/mg in the presence of 100 ng/ml human APRIL.
PubMed ID	1396583; 8165126; 11528522; 17825416; 10493829; 15616553; 10903733; 10801128; 10973284; 10908663; 12721620; 15542592

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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CSB-AP002271HU-1-datasheet.pdf

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Menge: 1 mg

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Lieferung vsl. bis 28.08.2025

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