« Zurück
Startseite /
Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor protein(MANF) (Active)

Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor protein(MANF) (Active)

ArtNr	CSB-AP002891HU-1
Hersteller	Cusabio
Menge	1 mg
Quantity options	1 mg 100 ug 25 ug 250 ug 5 ug 500 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Lyophilized powder
Specific against	Human (Homo sapiens)
Purity	>95% as determined by SDS-PAGE and HPLC.
Sequence	LRPGDCEVCI SYLGRFYQDL KDRDVTFSPA TI ENELIKFC REARGKENRL CYYIGATDDA ATKI INEVSK PLAHHIPVEK ICEKLKKKDS QICELK YDKQ IDLSTVDLKK LRVKELKKIL DDWGETCK GC AEKSDYIRKI NELMPKYAPK AASARTDL
Protein Familie	ARMET family
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Arginine-rich protein,
Lieferbar
Manufacturer - Category	Others / Others
Manufacturer - Conjugate / Tag	Tag-Free
Molecular Weight	18.2 kDa
General Research Areas	Neuroscience
Relevance	Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. {ECO:0000250, ECO:0000269\|PubMed:12794311, ECO:0000269\|PubMed:18561914}.
Function	Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
Subcellular Location	Secreted
Gene Names	MANF, ARMET, ARP
Endotoxin	Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer	0.2 um filtered PBS, pH 7.4 , lyophilized
Uniprot Entry Name	MANF_HUMAN
Expression Region	25-182aa
Protein Description	Full Length of Mature Protein
Biological Activity	Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 20 ug/ml, corresponding to a specific activity of ? 50 IU/mg.
PubMed ID	8649854; 15489334; 16641997; 12665801; 12794311; 15144186; 18561914; 21269460; 24275569; 19258449; 8971156; 9174057

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

CSB-AP002891HU-1-datasheet.pdf

Sicherheitsdatenblatt anfordern

Einfache Bestellung Periodische Bestellung

Menge: 1 mg

lieferbar

Lieferung vsl. bis 04.09.2025

Express-Lieferung: 3 Tage sparen

Vergleichen

Auf den Wunschzettel

Angebot anfordern