Recombinant Human Fibroblast growth factor 2(FGF2),partial (Active)

Cytokine / Growth Factor

17.4 kDa

FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family.The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4.

Secreted, Nucleus

MAPKsignalingpathway

Less than 1.0 EU/ug as determined by LAL method.

132-288aa

The ED50 as determined in a cell proliferation assay using BALB/c 3T3 cells is less than 10 ng/ml.