Hersteller |
Cusabio
|
Kategorie |
|
Typ |
Proteins Recombinant |
Specific against |
other |
Menge |
200ug |
Host |
E.coli |
ArtNr |
CSB-RP023944h-200 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Lieferbar |
|
Research areas |
Metabolism |
Target / Protein |
ENO1 |
Biologically active |
Not Test |
Expression system |
E.coli |
Species of origin |
Homo sapiens (Human) |
Uniprot ID |
P06733 |
AA Sequence |
SILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVP SGASTGIYEALELRDNDKTRYMGKGVSKAVEHINK TIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKF GANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNS EVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAA NFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEG GFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDV AASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYK SFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVV GDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVT ESLQACKLAQANGWGVMVSHRSGETEDTFIADLVV GLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKA KFAGRNF |
Tag Info |
N-terminal GST-tagged |
Expression Region |
2-428aa |
Protein length |
Partial |
MW |
73.4 kDa |
Alternative Name(s) |
2-phospho-D-glycerate hydro-lyaseC-myc promoter-binding protein; Enolase 1MBP-1MPB-1Non-neural enolase ; NNEPhosphopyruvate hydratasePlasminogen-binding protein |
Relevance |
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic syst due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. |
References |
Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase.Giallongo A., Feo S., Moore R., Croce C.M., Showe L.C.Proc. Natl. Acad. Sci. U.S.A. 83:6741-6745(1986) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.; FUNCTION |
Subcellular Location |
Cytoplasm, Cell membrane, Cytoplasm, myofibril, sarcomere, M line |
Protein Families |
Enolase family |
Tissue Specificity |
The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. |
Paythway |
HIF-1signalingpathway |
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