Manufacturer |
Cusabio
|
Category |
|
Type |
Proteins Recombinant |
Specific against |
other |
Amount |
200ug |
Host |
E.coli |
Item no. |
CSB-RP023944h-200 |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Research areas |
Metabolism |
Target / Protein |
ENO1 |
Biologically active |
Not Test |
Expression system |
E.coli |
Species of origin |
Homo sapiens (Human) |
Uniprot ID |
P06733 |
AA Sequence |
SILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVP SGASTGIYEALELRDNDKTRYMGKGVSKAVEHINK TIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKF GANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNS EVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAA NFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEG GFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDV AASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYK SFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVV GDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVT ESLQACKLAQANGWGVMVSHRSGETEDTFIADLVV GLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKA KFAGRNF |
Tag Info |
N-terminal GST-tagged |
Expression Region |
2-428aa |
Protein length |
Partial |
MW |
73.4 kDa |
Alternative Name(s) |
2-phospho-D-glycerate hydro-lyaseC-myc promoter-binding protein; Enolase 1MBP-1MPB-1Non-neural enolase ; NNEPhosphopyruvate hydratasePlasminogen-binding protein |
Relevance |
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic syst due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. |
References |
Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase.Giallongo A., Feo S., Moore R., Croce C.M., Showe L.C.Proc. Natl. Acad. Sci. U.S.A. 83:6741-6745(1986) |
Purity |
Greater than 90% as determined by SDS-PAGE. |
Storage |
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C. |
Notes |
Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week. |
Function |
Multifunctional enzyme that, as well as its role in glycolysis, plays a part in various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production.; FUNCTION |
Subcellular Location |
Cytoplasm, Cell membrane, Cytoplasm, myofibril, sarcomere, M line |
Protein Families |
Enolase family |
Tissue Specificity |
The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. |
Paythway |
HIF-1signalingpathway |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.