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Recombinant Human C-C motif chemokine 15 protein(CCL15) (Active)

ArtNr CSB-AP000581HU-25
Hersteller Cusabio
Menge 25 ug
Quantity options 1 mg 100 ug 25 ug 250 ug 5 ug 500 ug
Kategorie
Typ Proteins Recombinant
Format Lyophilized powder
Specific against other
Host E.coli
Purity >98% as determined by SDS-PAGE and HPLC.
Sequence SFHFAADCCT SYISQSIPCS LMKSYFETSS EC SKPGVIFL TKKGRQVCAK PSGPGVQDCM KKLK PYSI
Protein Familie Intercrine beta (chemokine CC) family
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias Chemokine CC-2, Leukotactin-1, LKN-1, MIP-1 delta, Macrophage inflammatory protein 5
Lieferbar
Manufacturer - Category
Cytokine / Chemokine
Manufacturer - Conjugate / Tag
Tag-Free
Molecular Weight
7.4 kDa
General Research Areas
Immunology
Relevance
Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. {ECO:0000269|PubMed:15905581}.
Function
Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
Subcellular Location
Secreted
Tissue Specificity
Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.
Paythway
Chemokinesignalingpathway
Gene Names
CCL15, MIP5, NCC3, SCYA15
Endotoxin
Less than 1.0 EU/ug as determined by LAL method.
Storage Buffer
0.2 um filtered PBS, pH 7.4 , lyophilized
Uniprot Entry Name
CCL15_HUMAN
Expression Region
46-113aa
Protein Description
Partial
Biological Activity
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 1.0-10 ng/ml.
PubMed ID
9548457; 9624581; 9600961; 10213461; 15489334; 15340161; 9129202; 9558365; 15905581; 10320325

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 25 ug
Lieferbar: In stock
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