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Recombinant Human T-cell surface glycoprotein CD8 alpha chain(CD8A),partial

Recombinant Human T-cell surface glycoprotein CD8 alpha chain(CD8A),partial

ArtNr	CSB-MP004966HU-10
Hersteller	Cusabio
Menge	10 ug
Quantity options	10 ug 100 ug 1 mg 20 ug 50 ug 500 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid or Lyophilized powder
Specific against	other
Host	Mammalian cells
Konjugat/Tag	Myc, HIS
Purity	Greater than 90% as determined by SDS-PAGE.
Sequence	SQFRVSPLDRTWNLGETVELKCQVLLSNPTSGCSW LFQPRGAAASPTFLLYLSQNKPKAAEGLDTQRFSG KRLGDTFVLTLSDFRRENEGYYFCSALSNSIMYFS HFVPVFLPAKPTTTPAPRPPTPAPTIASQPLSLRP EACRPAAGGAVHTRGLDFACD
Citations	"The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes."Littman D.R., Thomas Y., Maddon P.J., Chess L., Axel R.Cell 40:237-246(1985)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	T-lymphocyte differentiation antigen T8/Leu-2; CD_antigen: CD8a
Lieferbar
Manufacturer - Conjugate / Tag	N-terminal 6xHis-Myc-tagged
Storage Conditions	The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20C/-80C. The shelf life of lyophilized form is 12 months at -20C/-80C.
Molecular Weight	21.6 kDa
General Research Areas	Immunology
Relevance	Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.
Expression Region	22-182aa
Notes	Repeated freezing and thawing is not recommended. Store working aliquots at 4C for up to one week.
Function	Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule
Subcellular Location	Isoform 1: Cell membrane, Single-pass type I membrane protein
Tissue Specificity	CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homo-dimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.
Involvement in disease	CD8 deficiency, familial (CD8 deficiency)
Paythway	Antigenprocessingandpresentation
Biologically active	Not Test
Protein length	Extracellular Domain

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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CSB-MP004966HU-10-datasheet.pdf

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Menge: 10 ug

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Lieferung vsl. bis 28.08.2025

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