PD-1/CD279 Monoclonal Antibody

Store at -20C. Avoid freeze / thaw cycles.

PDCD1 (Programmed Cell Death 1) is a cell surface membrane protein of the immunoglobulin superfamily. It is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.Diseases associated with PDCD1 includeSystemic Lupus Erythematosus 2andMultiple Sclerosis, Disease Progression, Modifier Of. Among its related pathways areInnate Immune SystemandCD28 co-stimulation.

PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide.

IHC 1:100-1:200