ENPP7 Polyclonal Antibody

52kDa

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7(E-NPP 7) also known asalkaline sphingomyelin phosphodiesterase(Alk-SMase) orintestinal alkaline sphingomyelinaseis anenzymethat in humans is encoded by theENPP7gene. Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity. Inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Not inhibited by ADP, AMP and EDTA. Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon.

PBS with 0.05% sodium azide and 50% glycerol, pH 7.4

WB 1:500-1:2000, IHC 1:50-1:200

Synthetic peptide of human ENPP7