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Recombinant Human PDE1B Protein (His & GST Tag)

ArtNr ELS-PKSH031014-50ug
Hersteller Elabscience
Menge 50 ug
Quantity options 20 ug 50 ug
Kategorie
Typ Proteins
Format Lyophilized Powder
Specific against Human (Homo sapiens)
Host Insect Cells, Baculovirus-Infected Insect Cells
Konjugat/Tag HIS, GST
Purity > 94 % as determined by reducing SDS-PAGE.
Sequence Met 1-Asp 536
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias PDE1B1, PDES1B
Similar products PDE1B1, PDES1B
Versandbedingung Gekühlt
Lieferbar
Manufacturer - Category
Recombinant Proteins / Others
Manufacturer - Conjugate / Tag
N-His-GST
Shipping Temperature
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Calculated Molecular Weight
89.2 kDa
Observed Molecular Weight
75 kDa
Research Areas
Signal Transduction
Background
Calcium/calmodulin-dependent 3', 5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein which belongs to thecyclic nucleotide phosphodiesterase family and PDE1 subfamily. Phosphodiesterase-10A (PDE10A), Phosphodiesterase-1B (PDE1B), Phosphodiesterase-4B (PDE4B), and Phosphodiesterase-4A (PDE4A) are important regulators of signal transduction in striatum due to their catalysis of cyclic AMP and cyclic GMP. PDE1B is highly expressed in the striatum. It binds two divalent metal cations per subunit. Site one of PDE1B may preferentially bind zinc ions, while site two of PDE1B has a preference for magnesium and/or manganese ions. PDE1B is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. It has a preference for cGMP as a substrate.
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution
Please refer to the printed manual for detailed information.
Formulation
Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Activity
Not validated for activity

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 50 ug
Lieferbar: In stock
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