BMP-7, Human

Human BMP-7 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor ß (TGF-ß) superfamily. BMPs were, originally identified as, protein, regulators of cartilage and, bone formation. However, they havesince been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal, cells. BMP-7 is synthesized, as large, precursor molecules which are cleaved, by, proteolytic enzymes. The active, form can consist, of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.

Lyophilized from a 0.2µ, m filtered concentrated, solution in 30% acetonitrile, 0.1% TFA.

Cytokine, Chemokines & Growth Factors

This lyophilized preparation is stable at 2-8 C, but should be kept at -20 C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 C to -70 C. Avoid repeated freeze/thaw cycles.

Proteins

USA