Comparison

G-DNF, Human European Partner

Item no. Z02927-1
Manufacturer GenScript
Amount 1 mg
Quantity options 1 mg 10 ug 50 ug
Category
Type Proteins
Specific against Human (Homo sapiens)
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Sequence Ser78 – Ile211 (Accession # P39905)
Citations 1. Pascual, A. et al. (2011) J Mol Endocrinol 46: R83-R92Gauldie, J. et al. (1987) Proc. Natl. Acad. Sci. USA, 84, 7251-7255. 2. Roussa E. et al. (2009) Adv Exp Med Biol. 651:81-90. 3. Hong M. et al. (2008) Expert Rev Neurother. 8:1125-39. 4. Gordon, T. (2009) Neurosurg Focus. 26:E3. 5. Jing, S. et al. (1997). J. Biol. Chem. 272 (52): 33111–7, 6. Cik, M. et al. (2000). J. Biol. Chem. 275: 27505–12, 7. Takahashi, M. et al. (2001). Cytokine Growth Factor Rev. 12:361-73.
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias protein/Z02927_1-G_DNF_Human,Glial cell line-derived neurotrophic factor (G-DNF), is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems [1]. G-DNF, has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons [2] and motor neurons [3], as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human [4]. GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1 [5,6]. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) [7]. The, recombinant human G-DNF, expressed in CHO cells is disulfide-linked homo-dimer, with an apparent molecular weight of ca.30.4 kDa.</td></tr><tr><th>M.W.</th><td colspan="7"> 30.4 kDa (homo-dimer), observed by non-reducing SDS-PAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% as analyzed by SDS-PAGE and HPLC.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <0.2 EU/ug, determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50 1 x 103 units/mg</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant, human Glial cell line-derived neurotrophic factor (G-DNF), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhG-DNF should be stable up to 1 week at 4C or up to 2 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against PBS.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O or PBS at 100 ug/ml.</td></tr><tr><th>Sequence</th><td colspan="7"> Ser78 – Ile211 (Accession
Similar products G-DNF
Available
Specificity ED50 1 x 103 units/mg
Country of Origin
USA
Storage Conditions
Lyophilized recombinant, human Glial cell line-derived neurotrophic factor (G-DNF), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhG-DNF should be stable up to 1 week at 4C or up to 2 months at -20C.
Molecular Weight
30.4 kDa (homo-dimer), observed by non-reducing SDS-PAGE.
Product Line
Cytokine, Chemokines & Growth Factors
Manufacturer - Specificity
ED50 1 x 103 units/mg
Description
Glial cell line-derived neurotrophic factor (G-DNF), is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems [1]. G-DNF, has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons [2] and motor neurons [3], as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human [4]. GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1 [5, 6]. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) [7]. The, recombinant human G-DNF, expressed in CHO cells is disulfide-linked homo-dimer, with an apparent molecular weight of ca.30.4 kDa.
Reconstitution
Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation
Lyophilized after extensive dialysis against PBS.
Endotoxin Level
<0.2 EU/ug, determined by LAL method.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1 mg
Available: In stock
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