IP-10/CXCL10, Human

Hersteller GenScript
Kategorie
Typ Proteins
Specific against Human
Menge 1mg
ArtNr Z02971-1
Eclass 6.1 34160400
Eclass 9.0 42020190
Lieferbar
Product Line
Cytokines, Chemokines & Growth Factors
Description
IP-10/CXCL10, also known as CXCL10, is originally identified as an IFN-gamma-inducible gene in monocytes, fibroblasts and endothelial cells. It has since been shown that IP-10 mRNA is also induced by LPS, IL-1beta, TNF-alpha, IL-12 and viruses. Additional cell types that have been shown to express IP-10 include activated T-lymphocytes, splenocytes, keratinocytes, osteoblasts, astrocytes, and smooth muscle cells. IP-10 is also expressed in psoriatic and lepromatous lesions of skin. The mouse homologue of human IP-10, Crg-2, has been cloned and shown to share approximately 67% amino acid sequence identity with human IP-10.Recombinant, human IP-10/CXCL10 (rhIP-10), produced in E. coli is a single non-glycosylated polypeptide chain containing 78 amino acids. A fully biologically active molecule, rhIP-10 has a molecular mass of 8.6kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
M.W.
8.6 kDa, observed by reducing SDS-PAGE.
Purity
> 95% by SDS-PAGE and HPLC analyses.
Endotoxin Level
< 0.2 EU/ug, determined by LAL method.
Specific Activity
ED50, 5.0x 103 IU/mg.
Storage
Lyophilized recombinant, human IP-10/CXCL10 (rhIP-10), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rhIP-10 should be stable up to 2 weeks at 4C or up to 3 months at -20C.
Formulation
Lyophilized after extensive dialysis against 50mM Tris, pH8.0.
Reconstitution
Reconstituted in ddH2O at 100 ug/ml.
Sequence
Val22-Pro98 (accession number: P02778), expressed with an N-terminal Met.
Note
For research use only
Menge: 1mg
Lieferbar: In stock
Listenpreis: 1.057,76 €
Preis: 1.057,76 €
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