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IL-1β, Mouse

IL-1β, Mouse

ArtNr	Z02985-1
Hersteller	GenScript
Menge	1 mg
Quantity options	1 mg 10 ug 50 ug
Kategorie	Neuroscience Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Peptides & Proteins Recombinant Proteins Cell Biology Cell Movement Cell Adhesion Cell Culture Cytokines Cytoskeleton Cell Stainings ECM Cardiovascular Research Hypertension Intermediate filaments
Typ	Proteins
Specific against	Mouse (Murine, Mus musculus)
Purity	> 95% by SDS-PAGE and HPLC analyses.
Sequence	Val118-Ser269 (accession number:P10749), expressed with an N-terminal Met.
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein/Z02985_1-Interleukin_1_Beta_IL_1_Beta_Mouse,Interleukin-1 Beta (IL-1beta), is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine. Recombinant, mouse Interleukin-1 Beta(rmIL-1beta), produced in E. coli is a single non-glycosylated polypeptide chain containing 153 amino acids. A fully biologically active molecule, rmIL-1beta is obtained by proprietary chromatographic techniques at GenScript, with an apparent molecular weight of 17.5kDa analyzed by reducing SDS-PAGE.</td></tr><tr><th>M.W.</th><td colspan="7"> 17.5kDa, observed by reducing SDS-PAGE.</td></tr><tr><th>Purity</th><td colspan="7"> > 95% by SDS-PAGE and HPLC analyses.</td></tr><tr><th>Endotoxin Level</th><td colspan="7"> <0.2 EU/ug, determined by LAL method.</td></tr><tr><th>Specific Activity</th><td colspan="7"> ED50, 5.0× 108units/mg.</td></tr><tr><th>Storage</th><td colspan="7"> Lyophilized recombinant, mouseInterleukin-1 Beta(rmIL-1beta), remains stable up to 6 months at -80C from date of receipt. Upon reconstitution, rmIL-1beta should be stable up to 2 weeks at 4C or up to 3 months at -20C.</td></tr><tr><th>Formulation</th><td colspan="7"> Lyophilized after extensive dialysis against PBS.</td></tr><tr><th>Reconstitution</th><td colspan="7"> Reconstituted in ddH2O or PBS at 100 ug/ml.</td></tr><tr><th>Sequence</th><td colspan="7"> Val118-Ser269 (accession number:P10749), expressed with an N-terminal Met.</td></tr><tr><th>Note</th><td colspan="7"> For research use only</td></tr>
Similar products	Interleukin-1
Versandbedingung	Gekühlt
Lieferbar
Specificity	ED50, 5.0x 108units/mg.
Manufacturer - Category	Proteins
Country of Origin	USA
Shipping Temperature	4°C
Storage Conditions	-80°C
Molecular Weight	17.5kDa, observed by reducing SDS-PAGE.
Product Line	Cytokines
Manufacturer - Specificity	ED50, 5.0x 108units/mg.
Description	Interleukin-1 Beta (IL-1beta), is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine. Recombinant, mouse Interleukin-1 Beta(rmIL-1beta), produced in E. coli is a single non-glycosylated polypeptide chain containing 153 amino acids. A fully biologically active molecule, rmIL-1beta is obtained by proprietary chromatographic techniques at GenScript, with an apparent molecular weight of 17.5kDa analyzed by reducing SDS-PAGE.
Reconstitution	Reconstituted in ddH2O or PBS at 100 ug/ml.
Formulation	Lyophilized after extensive dialysis against PBS.
Endotoxin Level	<0.2 EU/ug, determined by LAL method.
Notes	For research use only

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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