LDL receptor [15C8]

ArtNr	20-272-192444
Hersteller	GENWAY
Menge	0.05 mg
Kategorie	Oncology Neuroscience Metabolism Targets for Rodent Neurosciences Antibodies Obesity Immunohistochemistry Immunoprecipitation Western Blot ELISA Immunocytochemistry Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody
Applikationen	WB, IP, IHC, ICC, ELISA
Clon	15C8
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-3379C7
Similar products	20-272-192444
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Genway ID:	GWB-3379C7
Clone:	15C8
Isotype:	IgG2aLight chain: kappa
Immunogen:	A trypic digest of low density lipoprotein receptor from bovine
Antigen Species:	Bovine
Positive Control:	Liver sections HT1080 cells HepG2 cells - Negative controls: HepG2 cells and normal skin
Target:	LDL receptor
Localization:	Cell Membrane and CytoplasmicStorage
Buffer:	0. 05M sodium phosphate containing 0. 2% gelatin and 0. 1% sodium azide
Application Note:	For ELISA: Use at a concentration of 0. 5-1 & micro; g/ml. For FACS: Use 5& micro; g (undiluted) to label 10^6 clells - Incubate for 30min at 4& ordm; C. For ICC: Use at a dilution of 1-5 & micro; g/ml. For IHC-Fr: Use at a dilution of 1-5 & micro; g/ml. For IP: Use at a dilution of 1-2 & micro; g/ml. For WB: Use at a dilution of 1-5 & micro; g/ml. Predicted
Molecular Weight:	160 kDa. Include 2mM Ca+2 with the antibody and avoid EDTA. Product 20-272-192444 has been reported to bind best to the unreduced LDL-R. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Target protein
Molecular Weight:	160kD Cellular
Localization:	Cell Membrane and Cytoplasmic Myeloma: Sp2/0-Ag14 The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase the rate-limiting step in cholesterol synthesis. At the same time a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder familial hypercholesterolemia.
Function:	Binds LDL the major cholesterol-carrying lipoprotein of plasma and transports it into cells by endocytosis. In order to be internalized the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection functions as a receptor for extracellular Tat in neurons mediating its internalization in uninfected cells.
Subunit:	Interacts with LDLRAP1. Interacts with SNX17. Interacts with HCV E1/E2 heterodimer. Interacts with HIV-1 Tat.
Subcellular Location:	Membrane; Single-pass type I membrane protein. Membrane clathrin-coated pit; Single-pass type I membrane protein.
Ptm:	N- and O-glycosylated.
Disease:	Defects in LDLR are the cause of familial hypercholesterolemia (FH) [MIM:143890]; a common autosomal semi-dominant disease that affects about 1 in 500 individuals. The receptor defect impairs the catabolism of LDL and the resultant elevation in plasma LDL-cholesterol promotes deposition of cholesterol in the skin (xanthelasma) tendons (xanthomas) and coronary arteries (atherosclerosis).
Similarity:	Belongs to the LDLR family.
Similarity:	Contains 3 EGF-like domains.
Similarity:	Contains 7 LDL-receptor class A domains.
Similarity:	Contains 6 LDL-receptor class B repeats.

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Menge: 0.05 mg

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Lieferung vsl. bis 28.08.2025