LDL receptor [15C8]

GWB-3379C7

IgG2aLight chain: kappa

Bovine

LDL receptor

0. 05M sodium phosphate containing 0. 2% gelatin and 0. 1% sodium azide

160 kDa. Include 2mM Ca+2 with the antibody and avoid EDTA. Product 20-272-192444 has been reported to bind best to the unreduced LDL-R. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. Target protein

Cell Membrane and Cytoplasmic Myeloma: Sp2/0-Ag14 The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase the rate-limiting step in cholesterol synthesis. At the same time a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder familial hypercholesterolemia.

Interacts with LDLRAP1. Interacts with SNX17. Interacts with HCV E1/E2 heterodimer. Interacts with HIV-1 Tat.

N- and O-glycosylated.

Belongs to the LDLR family.

Contains 7 LDL-receptor class A domains.