Gp200 [PN-15]

PN-15

Microsomal fraction of human renal cortical tissue homogenate

Normal Kidney or Renal Cell Carcinoma

Cell Membrane Cytoplasmic

200ug/ml of antibody purified from ascites fluid by Protein G chromatography. Prepared in 10mM PBS pH 7. 4 with 0. 2% BSA and 0. 09% sodium azide.

Cell Membrane Cytoplasmic In normal kidney gp200 is localized along the brush border of the pars convoluta and pars recta segments of the proximal tubule as well as focally along the luminal surface of Bowman\' s capsule adjoining the outgoing proximal tubule. Of other normal tissues examined the gp200 is also localized along the luminal surfaces of breast lobules and ducts the luminal surface of the epididymal tubular epithelium within the cytoplasm of parathyroid parenchymal cells and focally within the colloid of thyroid follicles. Thirty-one other normal tissues do not express similar or cross-reacting antigens. Reportedly gp200 is expressed by 93% of primary and 84% of metastatic renal cell carcinomas.

Membrane; Single-pass type I membrane protein (By similarity).

N-glycosylated.

Contains 10 C-type lectin domains.

Contains 1 ricin B-type lectin domain.