Ep-CAM

ArtNr	20-512-300036
Hersteller	GENWAY
Menge	0.1 mg
Kategorie	Oncology Antibodies By Cell Type Carcinoma Primary Antibodies By Organ Thyroid Cancer
Typ	Antibody
Clon	VU1D9
Specific against	other
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	GWB-D980E2
Similar products	20-512-300036
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Genway ID:	GWB-D980E2
Subclass:	IgG1
Clone:	VU1D9
Specificity:	VU1D9 reacts with the first EGF repeat in the extracellular domain of Ep-CAM. The epitope is sensitive for reducing agents. VU1D9 detects Ep-CAM in most simple. pseudostratified and transitional epithelia and in the majority of human carcinomas. VU1D9 is suitable for immunoblotting (non-reducing conditions). immunocytochemistry and immunohistochemistry on frozen and paraffin-embedded tissues and flow cytometry. Optimal antibody dilution should be determined by titration; recommended range is 1:25 ? 1:200 for flow cytometry. and for immunohistochemistry with avidin-biotinylated horseradish peroxidase complex (ABC) as detection reagent. and 1:100 ? 1:1000 for immunoblotting applications. Product
Note:	Each vial contains 100 ?l 1 mg/ml purified antibody in PBS containing 0. 02% sodium azide. 0. 1% BSA and 50% glycerol. Ep-CAM is a 40 kD glycoprotein. which functions as an epithelial cell adhesion molecule. Ep-CAM mediates Ca2+-independent homotypic interactions. Formation of Ep-CAM-mediated adhesions has a negative regulatory effect on adhesions mediated by classic cadherins. which may have strong effects on the differentiation and growth of epithelial cells. Ep- CAM overexpression was suggested to be associated with enhanced epithelial proliferation. Ep-CAM is expressed in the majority of human carcinomas and is a marker for tumors of epithelial lineage.
Function:	GA733 tumor-associated antigen gene family may function as growth factor receptors.
Subunit:	Monomer.
Subcellular Location:	Membrane; Single-pass type I membrane protein.
Tissue Specificity:	This protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas.
Similarity:	Contains 1 thyroglobulin type-1 domain. 1. Balzar M. Winter. M. J. de Boer. C. J. Litvinov S. V. (1999). The biology of the 17-1A antigen (Ep-CAM). J Mol Med 77. 699-712.

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Menge: 0.1 mg

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